有趣的是，Infigratinib最初于2021年获批用于胆管癌，后因适应症开发策略调整而主动撤回。如今，其有望在ACH赛道迎来“第二春”。基于其疗效和口服便利性，BridgeBio在今年的JPM大会上预测，该药Infigratinib将占据ACH治疗市场50%以上的份额。
Cite: Nai, C. “The Origins of Agar.” Asimov Press (2026). DOI: 10.62211/12pq-97ht
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For implementers, backpressure adds complexity without providing guarantees. The machinery to track queue sizes, compute desiredSize, and invoke pull() at the right times must all be implemented correctly. However, since these signals are advisory, all that work doesn't actually prevent the problems backpressure is supposed to solve.
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Екатерина Смирная (корреспондент отдела оперативной информации)